NGUYEN Dieu Lien Hoa, PhD

Natural Product and Medicinal Chemistry Lab
Department of Organic Chemistry
Faculty of Chemistry

University of Science, VNUHCM
Ho Chi Minh City, Vietnam
Tel: (+84) 287 3089 899

Scientific Education

- 1976-1981: BSc in Chemistry, University of Ho Chi Minh City

- 1996-1999: PhD in Chemistry, National University of Singapore

- 2003-2006: BA in English, University of Education in Ho Chi Minh City

Academic & Research Experience

- Investigating national resources through extraction, isolation, characterization and bio-testing of secondary metabolites in order to discover biologically active natural products with focus on cytotoxic, antioxidant, antidiabetic and anti-inflammatory properties.
- Semisynthesis of natural products in order to produce compounds with better bioactivity, better solubility and lower toxicity.
- Establishing data sets of standard substances for drug quality control of traditional medicine by providing HPLC fingerprint chromatograms, supplying pure bioactive substances corresponding with main peaks of the fingerprints, and building standards for drug quantity control.

Publication List (selected from 2013-now)

  1. Le-Thu T. Nguyen, Duc M. Nguyen, Lien-Hoa D. Nguyen. A new xanthone from the bark of Calophyllum thorelii, Natural Product Research, Vol. 27, pp. 563-567, 2013.
  2. Binh T. D. Trinh, Ngoc-Thao T. Nguyen, Ngoc T. N. Ngo, Phuong T. Tran, Le-Thu T. Nguyen, Lien-Hoa D. Nguyen. Polyisoprenylated benzophenone and xanthone constituents of the bark of Garcinia cochinchinensis, Phytochemistry Letters, Vol. 6, pp. 224-227, 2013.
  3. Danh A Bui, Minh K. Vu, Hiep D. Nguyen, Le-Thu T. Nguyen, Son V. Dang, Lien-Hoa D. Nguyen. A protostane and two lanostanes from the bark of Garcinia ferrea, Phytochemistry Letters, Vol. 10, pp. 123-126, 2014.
  4. Duong H. Trinh, Ly D. Ha, Phuong T. Tran, Lien-Hoa D. Nguyen. Isoprenylated xanthone and benzophenone constituents of the pericarp of Garcinia planchonii, Natural Product Communications, Vol. 9, pp. 1737-1740, 2014.
  5. Hau T. Vo, Ngoc T. N. Ngo, Thai Q. Bui, Hung D. Pham, Lien-Hoa D. Nguyen. Geranylated tetraoxygenated xanthones from the pericarp of Garcinia pedunculata, Phytochemistry Letters, Vol. 13, pp. 119-122, 2015.
  6. Thai Q. Bui, An T. Bui, Kien T. Nguyen, Vy T. Nguyen, Binh T. D. Trinh, Lien-Hoa D. Nguyen. A depsidone and six triterpenoids from the bark of Garcinia celebica, Tetrahedron Letters, V 57, pp. 2524-2529, 2016.
  7. Le-Thu T. Nguyen, Ngan T. D. D. T. Lai, Ly T. T. Nguyen, Hieu T. Nguyen, Duc M. Nguyen, Lien-Hoa D. Nguyen. Thoreliolides A and B, two polyisoprenylated benzoylphloroglucinol derivatives with a new carbon skeleton from the fruits of Calophyllum thorelii. Tetrahedron Letters, Vol. 57(25), pp. 2737-2741,
  8. Binh T. D. Trinh, Tam T. Quach, Dung N. Bui, Dan Staerk, Lien-Hoa D. Nguyen, Anna K. Jä Xanthones from the twigs of Garcinia oblongifolia and their anti-diabetic activity. Fitoterapia, Vol. 118, pp. 126-131, 2017.
  9. Chi N. Nguyen, Binh T. D. Trinh, Toan B. Tran, Le-Thu T. Nguyen, Anna K. Jäger, Lien-Hoa D. Nguyen. Anti-diabetic xanthones from the bark of Garcinia xanthochymus, Bioorganic & Medicinal Chemistry Letters, 27, pp. 3301-3304, 2017.
  10. Nam K. Nguyen, Xuyen A. Truong, Thai Q. Bui, Dzung N. Bui, Hai X. Nguyen, Phuong T. Tran, Lien-Hoa D. Nguyen. a-Glucosidase inhibitory xanthones from the roots of Garcinia fusca, Chemistry & Biodiversity, 2017 Oct, 14, e1700232. DOI: 10.1002/cbdv.201700232.
  11. Ly T. T. Nguyen, Huong K. T. Vo, Son Van Dang, Tho H. Le, Ly D. Ha, Le-Thu T. Nguyen, Lien-Hoa D. Nguyen. Labdane and norlabdane diterpenoids from the aerial parts of Leonurus japonicus, Phytochemistry Letters, Vol. 22, pp. 174-178, 2017.
  12. Binh T. D. Trinh, Hiep D. Nguyen, Hieu T. Nguyen, Phuoc D. Pham, Ngoc T. N. Ngo, Le-Thu T. Nguyen, Ly T. T. Nguyen, Dzung N. Bui, Dang Van Son, Lien-Hoa D. Nguyen. Cytotoxic limonoids from the bark of Walsura cochinchinensis, Fitoterapia, Vol. 133, pp. 75-79, 2019.
  13. Duong H. Trinh, Phuong T. Tran, Binh T.D. Trinh, Hieu T. Nguyen, Hiep D. Nguyen, Ly D. Ha, Lien-Hoa D. Nguyen. Coumarins and acridone alkaloids with a-glucosidase inhibitory and antioxidant activity from the roots of Paramignya trimera, Phytochemistry Letters, Vol. 35, pp. 94-98, 2020.