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NGUYEN Duc Hoang, PhD

Associate Professor,
Department of Microbiology
Faculty of Biology and Biotechnology
Director,
Center for Bioscience and Biotechnology
University of Science, VNUHCM
Ho Chi Minh City, Vietnam
Tel: (+84) 283830133
Email: ndhoang@hcmus.edu.vn

 

Scientific Education

Postdocs, 11/2006 – 05/2011, Max Planck Institute of Molecular Physiology, Dortmund, Germany

Ph.D. in Molecular Genetics/Biotechnology, 2003 – 2006, University of Bayreuth, Germany

MSc in Microbiology, 1999 – 2002, University of Science, Vietnam National University–Ho Chi Minh City (VNU-HCM), Vietnam

Diploma in Microbiology, 10/2000 – 9/2001 ‘International Post-Graduate University Course in Microbiology’, ICBiotech of Osaka University and Kyoto University

BSc in Biology, 1994 – 1998, University of Science, VNU-HCM, Vietnam.

Academic & Research Experience

* Biotechnology and applied microbiology:

  • Study, design and construct of expression system for Bacillus subtilis
  • Explore the capable of using Bacillus subtilis as a vaccine delivery vector
  • Expression and purification of proteins using E. coli, B. subtilis and Baculovirus expression system for biochemical analysis and industrial uses.

* Bioinformatics:

  • Study of microbial DNA genome to optimize gene expression
  • Study of blood- and food-borne pathogens to identify potential antigens.

* Biochemistry, molecular biology and biomedical research:

  • Application of supramolecules in biology
  • Using phage display and ribosome display for screening helical peptides, miniproteins and nanobody that bind to ligand binding domain of estrogen receptors, which is relevant to cancer repression
  • Discovery of inhibitors for kinase relevant to cancer repression.

* Organizing conferences:

 

  • The 1st International Conference on Applied Microbiology (ICAM 2016, http://icam-vn.com/) on December 6 – 9, 2016.
  • The 1st International Conference on Microbiology and One Health (MOH-VN 2018, http://2018.moh-vn.com/) on September 19 – 22, 2018. The 2nd International Conference on Microbiology and One Health (MOH-VN 2020, http://moh-vn.com/) will be organized on September 23 – 26, 2020.

Publication List (selected from 2013-now)

H index: 18                                                                Total times cited (Scopus): 900

Mendely: https://www.mendeley.com/impact/hoang-nguyen100/

[1] Dang DT, Nguyen HD, Merkx M, Brunsveld L. (2013). Supramolecular Control of Enzyme Activity through Cucurbit[8]uril-Mediated Dimerization. Angew Chem Int Ed Engl. 52(10): 2915–2919.

[2] Fuchs S*, Nguyen HD*, Phan TTP, Burton MF, Nieto L, Leeuwen IJV, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L. (2013). Proline Primed Helix Length as a Modulator of the Nuclear Receptor-Coactivator Interaction. JACS. 135: 4364-4371 (first author shared).

[3] Phan TTP, Nguyen HD, Wolfgang Schumann. (2013). Construction of a 5'-controllable stabilizing element (CoSE) for over-production of heterologous proteins at high levels in Bacillus subtilis. J Biotechnol. 168(1): 32-39.

[4] Richters A, Nguyen HD, Phan TTP, Simard JR, Grütter C, Engel J, Rauh D (2014) Identification of Type II and Type III DDR2 Inhibitors. J. Med. Chem. 57(10): 4252-4262.

[5] Fang Z, Simard JR, Plenker D, Nguyen HD, Phan TTP, Wolle P, Baumeister S, Rauh D (2015) Discovery of Inter-Domain Stabilizers - A Novel Assay System for Allosteric Akt Inhibitors, ACS Chem. Biol. 10(1): 279-288.

[6] Phan TTP, Tran LT, Wolfgang Schumann, Nguyen HD (2015) Development of Pgrac100-based expression vectors allowing high protein production levels in Bacillus subtilis and relatively low basal expression in Escherichia coli, Microb Cell Fact. 14(1): 72.

[7] Tran TA, Vo TN, Nguyen HD, Pham TB. (2015) A novel method to predict Highly Expressed Genes based on radius clustering and relative synonymous codon usage, Journal of computational biology 22(12):1986-1096.

[8] Becker C, Öcal S, Nguyen HD, Phan T, Keul M, Simard JR, Rauh D. (2016) Monitoring conformational changes in the receptor tyrosine kinase EGFR, ChemBioChem 17(11): 990-994.

[9] Trang Phan, Phuong Huynh, Tuom Truong, Hoang Duc Nguyen. (2017) A book chaper: A Generic Protocol for Intracellular Expression of Recombinant Proteins in Bacillus subtilis, Methods in Molecular Biology, Springer.

[10] Tran DTM, Phan TTP, Huynh TK, Dang NTK, Huynh PTK, Nguyen TM, Truong TTT, Tran TL, Schumann W, Nguyen HD. (2017) Development of inducer-free expression plasmids based on IPTG-inducible promoters for Bacillus subtilis, Microbial Cell Factories 16: 130.

[11] Le V, Phan T, Nguyen T, Brunsveld L, Schumann W, Nguyen H. 2019. Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells, Current Microbiology 76(12) 1477-1486 DOI: 10.1007/s00284-019-01783-9

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