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TRAN Van Hieu, PhD

Associate Professor,
Department of Molecular & Environmental Biotechnology
Faculty of Biology and Biotechnology
University of Science, VNUHCM
Ho Chi Minh City, Vietnam
Tel: (+84) 287 3089 899
Email:tvhieu@hcmus.edu.vn

Scientific Education

2016       Assoc.Prof. University of Science, VNU-HCM, Vietnam

2011        PhD. University of Wuerzburg, Germany

2006      MSc. University of Science, VNU-HCM, Vietnam

2003      BSc. University of Science, VNU-HCM, Vietnam

Academic & Research Experience

Academic Experience

Sep.2018-present: Vice Dean of Faculty

Oct. 2011-present: Deputy Head of Department

Jan, 2005-present: Lecture of Department

Oct, 2003-Dec, 2004: Teacher assistant of Department

Department of Molecular and Environmental Biotechnology

Faculty of Biology and Biotechnology

University of Science, University of Science, VNU-HCM, Vietnam.

Teaching Experience

PhD course

Cytokine and its role in immunomodulation

Master courses

Advanced molecular and cellular immunology

Immunity in disease and defense

Bachelor courses

Basic molecular and cellular immunology

Immunopathology and common immunological techniques

Practical work for Medical Biotechnology

Supervising Experience

PhD

Supervising: 3

Completed: 0

Master

Supervising: 14

Completed: 9

Bachelor

Supervising: 8

Completed: 41

Research Experience

Funded grants

 

  1. Computational custom-tailored design and biological synthesis of M-cell targeting peptide for oral vaccine development (4/2018-4/2019)
  2. Development of quantum dot based-labelling kit for cell staining (7/2017-7/2019)
  3. Isolation, structural determination of mucilage isolated from Ocimum basilicum Lamiaceae seeds and its application on weight management (12/2017-12/2019)
  4. Development and preliminary investigation of FGF-nanochitosan particles on murine fibroblast cells (3/2015-3/2017)
  5. Development of immuno-magnetic particles for cell separation using in bone-marrow transplantation (12/2013-12/2015)
  6. Expression, purification of recombinant human GM-CSF (granulocyte-macrophage colony stimulating factor) from yeasts and in vitro bioactivity evaluation (9/2013-9/2015)
  7. Expression and immunogenic evaluation of conserved epitopes of influenza virus A/H5N1 for human vaccine development (3-2013-3/2015)
  8. Development of nano-biosensor for liver cancer diagnosis (12/2010-12/2014)
  9. Generation of a recombinant yeast fabricating influenza virus A/H5N antigens on its cell surface and specific antibody evaluation (12-2006-12/2008).

 

 

Research Skills/Interests

  1. Vaccine development against ETEC associated diarrhea in swine: application of multi-epitope fusion antigen (MEFA) and genetic fusion antigens to develop multivalent vaccines against pathogenic E. coli and other bacterial and viral pathogens.
  2. Mucosal vaccines: in silico prediction and in vitro evaluation of peptides for mucosal- associated M-cell targeting.
  3. Exploiting GRAS organisms for vaccine delivery: application of edible organisms such as barker yeast for vaccine delivery.
  4. Recombinant glycoprotein production in yeasts: using barker yeast S. cerevisiae or methylotrophic P. pastoris for recombinant protein-based drug productio
  5. Applications of nano-sized particles: application of magnetic beads for cell separation, quantum dots for cell labelling.
  6. Applications of natural polymers for topical delivery: nano chitosan, nano cellulose, co‑polymer thin film for topical drug delivery on burn patients.

Publication List (selected from 2013-now)

  1. Stephanie Cartwright; Roslyn M Bill; Sy Tien Bui; Hieu Tran-Van; Hung Minh Nguyen. Rapid Expression and Purification of the Hepatitis Delta Virus Antigen using the Methylotropic Yeast Pichia pastoris. BMC Research Notes 10:340, 2017.
  2. Cong-Thuan Nguyen, Thanh-Thao Nguyen, Thu-Thuy Nguyen, Phuong-Phong T Nguyen, Anh- Dzung Nguyen, Linh-Thuoc Tran, Hieu Tran-Van. Preparation and in vitro evaluation of FGF-2 incorporated carboxymethyl chitosan nanoparticles. Carbohydrate Polymers 173:114–120, 2017.
  3. Anh-Minh Tran, Thanh-Thao Nguyen, Cong-Thuan Nguyen, Xuan-Mai Huynh-Thi, Tri Nguyen-Cao, Minh-Thuong Trinh, Thuoc Tran-Linh, Stephanie P Cartwright, Roslyn M Bill, Hieu Tran-Van. P. pastoris versus S. cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor. BMC Res Notes 10:148, 2017.
  4. Thi Kieu Hanh Ta, Minh-Thuong Trinh, Nguyen Viet Long, Thi Thanh My Nguyen, Thi Lien Thuong Nguyen, Tran Linh Thuoc, Bach Thang Phan, Derrick Mott, Shinya Maenosono, Hieu Tran-Van, Van Hieu Le. Synthesis and surface functionalization of anti-T-cell antibody coupled Fe3O4-SiO2-GPS-CDI core-shell nanoparticles for bio applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 504:376-383, 20
  5. Thuong Trinh-Minh, Viet-Ha Hoang, Thi-Kieu-Hanh Ta, Hieu Tran-Van. Conjugation of anti-CD3 antibody on magnetic beads via protein A/G for T cell-separating application. VNU Journal of Science: Natural Science and Technology, 38 (4S):408-414, 201
  6. Tat-Truong Dang, Cong-Thuan Nguyen, Hieu Tran-Van. Preparation and characterization nano chitosan for hGM-CSF release. Journal of Science and Technology Development, 18(3):62-71, 201
  7. Thanh-Thao Nguyen, Bich-Thao Nguyen, Hieu Tran-Van. Cloning, expression, purification and bioactivity identification of mGM-CSF (murine granulocyte macrophage- colony stimulating factor) in Escherichia coli. Journal of Biotechnology, 13(1): 47-53, 2015.
  8. Thanh-Thao Nguyen, Cao-Tri Nguyen, Hieu Tran-Van. Preparation and evaluation nano- chitosan for mGM-CSF release. Journal of Biotechnology, 13(2A): 581-587, 2015.
  9. Anh-Minh Nguyen, Thanh-Thao Nguyen, Stephanie P Cartwright, Roslyn M Bill, Hieu Tran- Van. Cloning, expression of recombinant protein hGM-CSF in Saccharomyces cerevisiae. Journal of Biotechnology, 13(2A):643-649, 2015.
  10. Cong-Thuan Nguyen, Hong-Ngoc Phan, Hieu Tran-Van. Development of bioassay for recombinant FGF-2 evaluation on NIH-3T3 cell. Journal of biotechnology 13(2A): 559-565, 201
  11. Tat-Truong Dang, Hieu Tran-Van. Preparation and characterization nano chitosan for FGF-1 (fibroblast growth factor 1) release. Journal of biotechnology 13(2A):551-557, 2015.
  12. Phu-Sang Nguyen, Thanh-Thao Nguyen, Hieu Tran-Van. Cloning, periplasmic expression and purification of human granulocyte-macrophage colony stimulating factor (hGM-CSF) in Escherichia coli. Science & Technology Development, 17(4): 12-19, 2014.
  13. Tat-Truong Dang, Minh-Thuong Trinh, Hieu Tran-Van. Cloning, expression and purification of human fibroblast growth factor 1 (FGF 1) in Escherichia coli. Journal of biotechnology, 12(4):615-621, 2014.
  14. Kim-Lien Pham, Tat-Truong Dang, Hieu Tran-Van. Cloning and expression of human granulocyte-macrophage colony stimulating factor (hGM-CSF) in Pichia pastoris. Science & Technology Development, 16(3): 22-28, 2013.

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