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NGUYEN Thi Thanh Mai, PhD

Professor,
Department of Medicinal Chemistry
Faculty of Chemistry

University of Science, VNUHCM
Ho Chi Minh City, Vietnam
Tel: (+84) 28 3835 5270
Email:nttmai@hcmus.edu.vn

Scientific Education

  • 2005: PhD in Pharmaceutical, Toyama University, Japan
  • 2000: MSc. in Analytical chemistry, University of Science, VNUHCM
  • 1996: BSc. in Analytical chemistry, University of Science, VNUHCM

Academic & Research Experience

Drug discovery and development. Until now, I screened thousand extracts prepared from Vietnamese medicinal plants for antioxidant, anticancer, inhibiting of enzymes such as xanthine oxidase, tyrosinase, acetylcholinesterase, α-glucosidase. I also isolated more than 500 natural compounds, among them more than 100 were new compounds.

Publication List (selected from 2013-now)

  1. Phu Hoang Dang, Tho Huu Le, Truong Nhat Van Do, Hai Xuan Nguyen, Mai Thanh Thi Nguyen, Nhan Trung Nguyen. Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae). Zeitschrift für Naturforschung C,2021, 76(1-2), 49-53.
  2. Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Tho Huu Le, Truong Nhat Van Do, Ashraf M. Omar, Suresh Awale, Nhan Trung Nguyen. Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. Phytochemistry, 2021, 183, 112464, DOI: 1016/j.phytochem.2020.112646.
  3. Phu Hoang Dang, Tho Huu Le , Truong Nhat Van Do, Hai Xuan Nguyen, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Diarylalkanoids as potent tyrosinase inhibitors from the stems of Semecarpus caudate, Evidence-Based Complementary and Alternative Medicine, 2021, doi: 10.1155/2021/8872920
  4. Nhan Trung Nguyen, Phu Hoang Dang, Hai Xuan Nguyen, Tho Huu Le, Truong Nhat Van Do, Mai Thanh Thi Nguyen, A new lignan from the stems of Buchanania lucida Blume (Anacardiaceae), Natural Product Research, 2021, doi: 1080/14786419.2020.1871341
  5. A new cytotoxic cardenolide from the roots of Calotropis gigantea, Natural Product Research, 2020, https://doi.org/10.1080/14786419.2020.1781114 .
  6. Nam Ngoc Pham, Cho-Yi Chen, Hung Li, Mai Thanh Thi Nguyen, Phung Kim Phi Nguyen, Shen-Long Tsai, June-Yen Chou, Theresia Cecylia Ramli, Yu-Chen Hu, Engineering Stable Pseudomonas putida S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production, ACS Synthetic Biology, 2020, 9(5), 1138-1149.
  7. Mai Thanh Thi Nguyen, Phu Hoang Dang,Hai Xuan Nguyen,Tho Huu Le, Truong Nhat Van Do, Phuc Van Pham, Sinh Truong Nguyen, Nhan Trung Nguyen. Paratrimerin I, cytotoxic acridone alkaloid from the roots of Paramignya trimera, Natural Product Research, 2020, doi:10.1080/14786419.2020.1774760.
  8. Nhan Lu-Chinh Phan, Khuong Duy Pham, Phong Le Minh, Mai Thanh Thi Nguyen, Ngoc Phan Kim, Kiet Dinh Truong, Phuc Van Pham. Hopea odorata extract can efficiently kill breast cancer cells and cancer stem-like cells in three-dimensional culture more than in monolayer cell culture, Advances in Experimental Medicine and Biology, 2020, doi: 10.1007/5584_2020_524.
  9. Sinh Truong Nguyen, Nghia Minh Do, Duyen Ho-Khanh Tran, Ngoc Bao To, Phuc Hong Vo, Mai Thi Thanh Nguyen, Nhan Trung Nguyen, Hai Xuan Nguyen, Kiet Dinh Truong, Phuc Van Pham. Isopanduratin A isolated from Boesenbergia pandurata reduces HepG2 Hepatocellular carcinoma cell proliferation in both monolayer and three-dimensional cultures, Advances in Experimental Medicine and Biology, 2020, doi: 1007/5584_2020_523.
  10. Le Huu Tho, Do Van Nhat Truong, Nguyen Xuan Hai, Dang Hoang Phu, Nguyen Trung Nhan, Nguyen Thi Thanh Mai, A new phenylheptanoid from the leaves of Gnetum gnemon, Natural Product Research, 2020, doi:10.1080/14786419.2020.1753055.
  11. Nguyen Thi Thanh Mai, Nguyen Huu Duy Khang, Dang Hoang Phu, Nguyen Xuan Hai, Suresh Awale, Nguyen Trung Nhan, Calosides A−F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity, Journal of Natural Products, 2020, 83, 385-391.
  12. Nguyen Xuan Hai, Nguyen Thanh Loc, Do Van Nhat Truong, Le Huu Tho, Dang Hoang Phu, Tran Manh Hung, Nguyen Trung Nhan, Nguyen Thi Thanh Mai. A new phenolic acid from the wood of Mangifera gedebe, Natural Product Research, 2019, doi:10.1080/14786419.2019.1680666.
  13. Nguyen Truong Sinh, Le Van Manh Hung, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Nguyen Xuan Hai, Phan Kim Ngoc, Dinh Truong Kiet, Pham Van Phuc, In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells, Biomedical Research and Therapy, 2019, 6(8):3325-3332.
  14. Dang Hoang Phu, Nguyen Thi Thuy Linh, Nguyen Thi Thu Hue, Le Huu Tho, Do Van Nhat Truong, Nguyen Xuan Hai, Le Dinh Nghia, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, A new dimeric alkylresorcinol from the stem barks of Swintonia floribunda (Anacardiaceae), Natural Product Research, 2019, 33(20), 2883-2889.
  15. Riho Tanigaki, Riku Takahashi, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Truong Van Nhan Do, Nguyen Xuan Hai, Takao Kataoka, 4-Hydroxypanduratin A and isopanduratin A inhibit tumor necrosis factor -stimulated gene expression and the nuclear factor kB-dependent signaling pathway in human lung adenocarcinoma A549 cells, Biological and Pharmaceutical Bulletin, 2019, 42, 26-33.
  16. Dang Hoang Phu, Nguyen Thi Tinh, Le Huu Tho, Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Nguyen Trung Nhan. A new bischromanone from the stems of Semecarpus caudata, Natural Product Research, 2018, 32,1745-1750.
  17. Can Van Mao, Tran Hai Anh, Pham Minh Dam, Dinh Quoc Bao, Le Van Quan, Nguyen Van Ba, Nguyen Thi Thanh Mai, Nguyen Xuan Hai, Nguyen Trung Nhan, Hisao Nishijo. Willughbeia cochinchinensis ameliorates scopolamine-induced deficits in memory, spatial learning, and object recognition in rodents. Journal of Ethnopharmacology, 2018, 214, 99-105.
  18. Do Van Nhat Truong, Nguyen Xuan Hai, Le Huu Tho, Ngo Thi My Trang, Dang Hoang Phu, Phung Hieu Nghia, Vo Trong Nghia, Nguyen Minh Duc, Le Thi Hong Nhan, Le Thanh Thanh, Nguyen Thi Thanh Mai, Suresh Awale, Nguyen Trung Nhan, A New Compound from the Rhizomes of Boesenbergia pandurata, Natural Product Communications, 2018, 13 (6), 739-740.
  19. Dang Hoang Phu, Pham Thi Kim Hang, Phan Nguyen Huu Trong, Nguyen Huu Duy Khang, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, A new 20-deoxypseudojujubogenin glycoside from Bacopa monniera, Chemistry of Natural Compounds, 2018, 54 (1), 124-126.
  20. Nguyen Xuan Hai, Do Van Nhat Truong, Nguyen Thi Thanh Mai, Dang Hoang Phu, Le Huu Tho, Suresh Awale, Nguyen Trung Nhan, A New Alkenylphenol from the Propolis of Stingless Bee Trigona minor, Natural Product Communications, 2018, 13(1), 69-70.
  21. Nguyen Thi Thanh Mai, Dang Hoang Phu, Nguyen Ngoc Tu, Bui Thi Thuy Linh, Nguyen Xuan Hai, Le Huu Tho, Do Van Nhat Truong, Nguyen Trung Nhan, Paratrimerins G and H, two prenylated phenolic compounds from the stems of Paramignya trimera, Phytochemistry Letters, 2018, 23, 78–82.
  • Nguyen Thi Thanh Mai, Le Huu Tho, Nguyen Xuan Hai, Dang Hoang Phu, Truong Van Nhat Do, Manabu Abe, Ryukichi Takagi, Nguyen Trung Nhan. Artocarmins G–M, prenylated 4-chromenones from the stems of Artocarpus rigida and their tyrosinase inhibitory activities, Journal of Natural Products, 2017, 80, 3172−3178.
  1. Nguyen Truong Sinh, Huynh Linh Khanh, Nguyen Thi Lam Huyen, Mai Nguyen Thi Thanh, Nhan Nguyen Trung, Hai Nguyen Xuan, Ngoc Phan Kim, Dinh Truong Kiet, Pham Van Phuc, Hopea odorata extract inhibits hepatocellular carcinoma via induction of caspase-dependent apoptosis, OncoTargets and Therapy, 2017, 10, 5765–5774.
  2. Nguyen Trung Nhan, Dang Hoang Phu, Vu Thi Xuan Ngoc, Le Huu Tho, Nguyen Thi Thanh Mai, Quinoliniumolate and 2H-1,2,3-triazole derivatives from the stem of Paramignya trimera and their α-glucosidase inhibitory activities: in vitro and in silico studies, Journal of Natural Products, 2017, 80, 2151-2155.
  3. Dang Hoang Phu, Nguyen Thi Hong Hanh, Truong Thi Thanh Hien, Do Van Nhat Truong, Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Manabu Abe, Ryukichi Takagi, Nguyen Trung Nhan, Two ring opened-oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana, Tetrahedron Letters, 2017, 58, 3897-3900.
  4. Nguyen Hoai Phuong, Nguyen Thi Thuy Linh, Nguyen Trung Duc, Nguyen Thi Anh Tuyet, Nguyen Thi Thanh Mai, Nguyen Kim Phi Phung, A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa, Natural Product Communications, 2017, 12 (11), 1751-1754.
  5. Dang Hoang Phu, Nguyen Xuan Hai, Nguyen Thi Hong Hanh, Vo Duy Thai, Le Huu Tho, Phan Nguyen Huu Trong, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Lignans from the roots of Taxus wallichiana and their α‑glucosidase inhibitory activities, Journal of Natural Products, 2017, 80, 1876-1882.
  6. Le Huu Tho, Nguyen Xuan Hai, Truong Van Nhat Do, Dang Hoang Phu, Nguyen Trung Nhan, Nguyen Thi Thanh Mai, Moracin VN, A New Tyrosinase and Xanthine Oxidase Inhibitor from the Woods of Artocarpus heterophyllus, Natural Product Communications, 2017, 12 (6), 925-927.
  7. Duong Thi Thanh Truc, Do Van Nhat Truong, Nguyen Xuan Hai, Le Huu Tho, Dang Hoang Phu, Nguyen Trung Nhan, Nguyen Thi Ngoc Tuyen, Nguyen Diep Thao, Nguyen Thi Thanh Mai. α-Glucosidase inhibitors from the stem of Mangifera reba, Tetrahedron Letters, 2017, 58, 2280-2283.
  8. Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Suresh Awale, Chemical Constituents of propolis from Vietnamese Trigona minor and their antiausterity activity against the PANC-1 human pancreatic cancer cell line, Journal of Natural Products, 2017, 80, 2345-2352.
  9. Dang Hoang Phu, Nguyen Xuan Hai, Duong Thi Thanh Truc, Tran Thi Kim Thao, Nguyen Thi Phuc, Vu Thi Kieu Trang, Vuong Chi Hung, Phan Nguyen Huu Trong, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Suresh Awale, α‑Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana, Journal of Natural Products, 2017, 80, 1087-1095.
  10. Dang Hoang Phu, Le Huu Tho, Phan Thi Kim Phuong, Le Thi Tuyet Phuong, Nguyen Thi Thanh Mai, Nguyen Trung Nhan. Two acridones and two coumarins from the roots of Paramignya trimera, Tetrahedron Letters, 2017, 58, 1553-1557.
  • Nguyen Trung Nhan, Nguyen Thi Thanh Mai, Nguyen Xuan Hai, Dang Hoang Phu, Dya Fita Dibwe, Hiroyasu Esumi, Suresh Awale, Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC‑1 Human Pancreatic Cancer Line, Journal of Natural Products, 2017, 80, 141-148.
  1. Nguyen Huu Duy Khang, Dang Hoang Phu, Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Suresh Awale, Nguyen Trung Nhan, Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 2902–2906.
  2. Bui Huu Trung, Nguyen Trung Nhan, Dang Hoang Phu, Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors, SpringerPlus, 2016, 5, 2-8.
  3. Nguyen Xuan Hai, Do Van Nhat Truong, Le Huu Tho, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Hiroyasu Esumi, Suresh Awale, Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC‑1 Human Pancreatic Cancer Cell Line, Journal of Natural Products, 79, 2016, 2053-2059.
  4. Nguyen Xuan Hai, Le Cong Tri, Do Van Nhat Truong, Le Huu Tho, Nguyen Trung Nhan, Nguyen Thi Thanh Mai, α‑Glucosidase inhibitors from the bark of Mangifera mekongensis, Chemistry Central Journal, 2016, 10:45, 1-6.
  5. Lam Thi My Linh, Nguyen Thi Thanh Mai, Nguyen Xuan Hai, Dang Hoang Phu, Nguyen Trung Nhan,Tran Manh Hung, Nguyen Thi Hoa, Nguyen Minh Nui, Byung Sun Min, Jeong Ah Kim, Jae Sue Choi, Can Van Mao, Anti‑cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa, Chemistry Central Journal, 2016, 10 (48), 1-10.
  6. Nguyen Xuan Hai, Nguyen Trung Nhan, Dang Hoang Phu, Ho Thi Phuoc, Nguyen Thi Thanh Mai, Can Van Mao, Dya Fita Dibwe, Jun-ya Ueda, Suresh Awale, Cassane diterpenes from the seed kernels of Caesalpinia sappan, Phytochemistry, 2016, 122, 286-293.
  7. Nguyen Xuan Hai, Nguyen Trung Nhan, Nguyen Khoa Ha Mai, Le Huu Tho, Do Van Nhat Truong, Tran Manh Hung, Nguyen Thi Thanh Mai, Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllus, Chemistry Central Journal, 2016, 10 (2), 1-6.
  8. Nguyen Xuan Hai, Nguyen Trung Nhan, Dang Hoang Phu, Ho Thi Phuoc, Nguyen Thi Thanh Mai, Can Van Mao, Dya Fita Dibwe, Jun-ya Ueda, Suresh Awale, A new cassane-type diterpenes from the seed of Caesalpinia sappan, Natural Product Communications, 2016, 11 (6), 723-724.
  9. Phan Thi Anh Dao, Tran Le Quan, Nguyen Thi Thanh Mai, Constituents of the Stem of Nauclea orientalis, Natural Product Communications, 2015, 10 (11), 1901-1903.
  10. Dang Hoang Phu, Nguyen Trung Nhan, Nguyen Xuan Hai, Nguyen Bao Luan, Le Huu Tho, Do Van Nhat Truong, Can Van Mao, Nguyen Thi Thanh Mai, α-Glucosidase inhibitors from the leaves of Embelia ribes, Fitoterapia, 2015, 100, 201–207.
  11. Dang Hoang Phu, Nguyen Thi Thanh Mai, Nguyen Xuan Hai, Vu Thi Thuy Dung, Truong Van Son, Nguyen Trung Nhan, Three new cassane-type furanoditerpenes from the seed of Vietnamese Caesalpinia bonducella, Phytochemistry Letters, 2015, 13, 99–102.
  12. Manh Hung Tran, Mai Thi Thanh Nguyen, Hai Dang Nguyen, Nguyen Dat Tien, Phuong Thuong Thien, Cytotoxic constituents from the seeds of Vietnamese Caesalpinia sappan, Pharmaceutical Biology, 2015, 53(10), 1549-1554.
  13. Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Nguyen Huu Duy Khang, Dau Thi Thu Hien, Nguyen Xuan Hai, Dang Hoang Phu, Le Minh Tam, Phan Nguyen Huu Trong, Tran Hai Anh, Nguyen Duy Bac, Jun-ya Ueda, Suresh Awale. Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity, Planta Medica, 2014, 80 (2/3), 193-200.
  14. Dang Hoang Phu, Nguyen Xuan Hai, Nguyen Trung Nhan, Le Thi Ngoc Hanh, Nguyen Thi Thanh Mai, α-Glucosidase inhibitor from the stems of Embelia ribes. Phytotherapy Research, 2014, 28, 1632-1636.
  15. Phan Thi Anh Dao, Tran Le Quan, Nguyen Thi Thanh Mai, Antioxidant constituents from the stem of Tetrastigma erusbescense (Vitacea), Natural Product Siences, 2014, 20 (1), 22-28.
  16. Nguyen Xuan Hai, Nguyen Thi Thanh Mai, Nguyen Anh Thy, Nguyen Thi Y Nhi, Phan Thi Anh Dao, Thi Ho Phuoc, Phan Nguyen Huu Trong, Dang Hoang Phu, Nguyen Trung Nhan, Jun-ya Ueda, Suresh Awale. Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line, Fitoterapia, 2013, 91, 148-153.
  17. Nguyen Thi Thanh Mai, Nguyen Trung Nhan, A new lupane triterpene from Tetracera scandens L., xanthine oxidase inhibitor, Natural Product Research, 2013, 27 (1), 61-67

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