Faculty of Biology - Biotechnology

PositionHead of the Laboratory of Cancer Research, Former Rector of VNUHCM-University of Science
Citation nameTrần Linh Thước, Linh Thuoc Tran, Thuoc Linh Tran
Field of ProfessionalBasic and Applied Microbiology
Gene technology
Molecular Biotechnology
Down-Stream Process
Year of appointment title of Professor2002
Style of citationAPA Citation Style
EducationIn 1983
University of Ho Chi Minh City
BSc of Biology
In 1992
Kyoto University, Japan
MSc of Agronomy, majoring in Microbiology and Food Science and Technology
In 1995
Kyoto University, Japan
DSc of of Agronomy, majoring in Microbiology and Food Science and Technology
Vietnamese, English, French, Japanese


Từ 2017-2022
1. Anh-Minh Tran, Thanh-Thao Nguyen, Cong-Thuan Nguyen, Xuan-Mai Huynh-Thi, Cao-Tri Nguyen, Minh-Thuong Trinh, Linh-Thuoc Tran, Stephanie P. Cartwright, Roslyn M. Bill, Hieu Tran-Van, Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor, BMC Research Notes. 2017 Apr 4;10(1):148. doi: 10.1186/s13104-017-2471-6. 2017.
2. Cong-Thuan Nguyen, Thanh-Thao Nguyen, Thu-Thuy Nguyen, Phuong Phong Thi Nguyen, Anh Dzung Nguyen, Linh Thuoc Tran, Hieu Tran-Van, Preparation and in vitro evaluation of FGF-2 incorporated carboxymethyl chitosan nanoparticles, Carbohydrate Polymer. 2017 Oct 1;173:114-120. doi: 10.1016/j.carbpol.2017.05.080. 2017.
3. Dinh Thi Minh Tran, Trang Thi Phuong Phan, Thanh Kieu Huynh, Ngan Thi Kim Dang, Phuong Thi Kim Huynh, Tri Minh Nguyen, Tuom Thi Tinh Truong, Thuoc Linh Tran, Wolfgang Schumann, Hoang Duc Nguyen, Development of inducer-free expression plasmids based on IPTG-inducible promoters for Bacillus subtilis, Microbial Cell Factories, 2017 Jul 25;16(1):130. doi: 10.1186/s12934-017-0747-0. 2017.
4. Quyen Vu Dang Ha, Oanh Truong Thi, Phuong Thai Thi Lan, Thuoc Tran Linh, Binh Dang Thuy, Molecular phylogeny of catfish (Teleostei: Siluriformes) inferred from mitochondrial markers – implications for lower Mekong River Basin, European Journal of Advanced Research in Biological and Life Sciences, 6 (3), 1-12, 2018.
5. Thi Thanh Nguyen, My Dung Vuu, Man Anh Huynh, Masamitsu Yamaguchi, Linh Thuoc Tran, Thi Phuong Thao Dang, Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown, Oxidative Medicine and Cellular Longevity, 2018 Jul 3;2018:2038267. doi: 10.1155/2018/ 2038267.
6. B.T. Dang, Q.H.D. Vu, E.E. Biesack, T.V. Doan, O.T. Truong, T.L. Tran, A.S. Ackiss, B.L. Stockwell,  K.E. Carpenter, Population genomics of the peripheral freshwater fish Polynemus melanochir (Perciformes Polynemidae) in a changing Mekong Delta, Conservation Genetics, 20, 961–97, 2019.
7. Thanh-Hoa Nguyen-Thi, Kien-Quang Huynh, Phuong-Linh Dinh-Thi, Linh-Thuoc Tran, YongSuk Jang, Hieu Tran-Van. Expression, Purification, and In Vivo Evaluation of GFP-Fused M Cell Targeting Receptor Binding Domain of Protein FimH, Protein and Peptide Letters, 26, 1-7, 2019.
8. Bao-Chau Thi Tran, Hai-Vy Vo-Nguyen, Viet-Anh Nguyen, Thuoc Linh Tran, Hieu Tran-Van, FliC-delta220-320 from Salmonella enteritidis as an Adjuvant for Vaccine Development, SSR Institute of International Journal of Life Sciences, 6(2):2494-2501, 2020.
9. Duy Nguyen-Le, My-Tien Ngo, Minh-Tuan Vo, Thuoc Linh Tran, Hieu Tran-Van, Effects of Astaxanthin on Body and Liver Weight of High-Fat Diet through Regulation of Peroxisome Proliferator-Activated Receptors (PPARs), SSR Institute of International Journal of Life Sciences, 6(2):2502-2508, 2020.
10. Hong-Diep Thi Tran, Khanh-Thien Le, Thuy-Dung Mai-Hoang, Thuoc Linh Tran, Hieu Tran-Van, Application of Antibody-Conjugated CdSe/MSA Quantum dots on Immunohistochemistry, SSR Institute of International Journal of Life Sciences, 6(2):2520-2527, 2020.
11. Kim-Hang Thi-Ngo, Duy Nguyen-Le, Thanh Nguyen-Phuoc, Thuoc Linh Tran, Hieu Tran-Van, Cloning, Expression and Purification of Recombinant Interleukin 1 Receptor Antagonist (IL-1RA) in Escherichia coli, SSR Institute of International Journal of Life Sciences, 6(3):2538-2535, 2020.
12. Thao Suong Tran-Nguyen, Dang-Thuc Ngo-Luong, Khai-Hoan Nguyen-Phuoc, Thuoc Linh Tran, Hieu Tran-Van, Simultaneously targeting nitrocellulose and antibody by a dual-headed protein, Protein Expression and Purification, 177:105764; doi: 10.1016/j.pep.2020. 105764; 2021.
13. Truong Thi Bich Ngoc, Nguyen Thi Hoai Nga, Nguyen Thi My Trinh, Tran Linh Thuoc, Dang Thi Phuong Thao, Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells, Journal of Ethnopharmacology, 263, 113-222, 2020.
14. Nguyen Thi Hoai Nga, Truong Thi Bich Ngoc, Nguyen Thi My Trinh, Tran Linh Thuoc, Dang Thi Phuong Thao, Optimization and application of MTT assay in determining density of suspension cells, Analytical Biochemistry, Vol. 610, 1, 113937, 2020.
15. Dinh Thi Minh Tran, Trang Thi Phuong Phan, Thanh Thi Ngoc Doan, Thuoc Linh Tran, Wolfgang Schumann, Hoang Duc Nguyen, Integrative expression vectors with Pgrac promoters for inducer-free overproduction of recombinant proteins in Bacillus subtilis, Biotechnology Reports, 28:e00540. doi: 10.1016/j.btre.2020.e00540; 2020.
16. Thuy-Dung Mai-Hoang, Hai-Ly Tien, Hai-Minh Chau-Hoang, Khai-Hoan Nguyen-Phuoc, Hung Quoc Pham, Thuoc Linh Tran, Hieu Tran-Van, A novel PCR method for simultaneously detecting Acute Hepatopancreatic Necrosis Disease (AHPND) and mutant-AHPND in shrimp, Aquaculture,  534, 736336; 10.1016/j.aquaculture.2020.736336; 2021.
17. Thu-Minh Tran-Nguyen, Khanh-Thien Le, Le-Giang Thi Nguyen, Thanh-Loan Thi Tran, Phuong-Cac Hoang-Thai, Thuoc Linh Tran, Sik-Loo Tan & Hieu Tran-Van, Third degree burn mouse treatment using recombinant human fibroblast growth factor 2, Growth Factors, 8(5-6):282-290. doi: 10.1080/08977194.2021.1967342; 2021.
18. Nguyen Thi My Trinh, Tran Linh Thuoc, Dang Thi Phuong Thao, Production of recombinant human G-CSF from non-classical inclusion bodies in Escherichia coli, Brazilian Journal of Microbiology,  52(2): 541–546;; 2021.
19. Ngoc-Diem Duong, Khai-Hoan Nguyen-Phuoc, Kim-Yen Thi Do, Nguyet-Thu Thi Nguyen, Thuoc Linh Tran, Hieu Tran-Van, Production of polyclonal antibody against the recombinant PirBvp protein of Vibrio parahaemolyticus, Journal of Genetic Engineering and Biotechnology, 19:70; doi: 10.1186/s43141-021-00172-9; 2021.
20. Duy Nguyen-Le, Cao-Tri Nguyen, Quang Ton-That, Thuoc Linh Tran, Hieu Tran-Van, Extraction and evaluation of lipid entrapment ability of Ocimum basilicum L. seed mucilage, Indian Journal of Pharmaceutical Education and Research, 53(3):880-887;; 2021.
21. Khai-Hoan Nguyen-Phuoc, Ngoc-Diem Duong, Thach Van Phan, Kim-Yen Thi Do,  Nguyet-Thu Thi Nguyen, Thuoc Linh Tran, Hieu Tran-Van, Generation and evaluation of polyclonal antibodies specific for ToxA from Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease (AHPND) in shrimp, Molecular Biology Research Communications, 10(1):23-32, 2021.
22. Thong Truong, Thai Loc Hoang, Linh Thuoc Tran, Thi Phuong Thuy Pham, Thai-Hoang Le, Prevalence of Antibiotic Resistance Genes in the Saigon River Impacted by Anthropogenic Activities, Water, 13, 2234;; 2021.
23. Tran Dang Thanh Tam, Truong Thi Bich Ngoc, Nguyen Thi Hoai Nga, Nguyen Thi My Trinh, Tran Linh Thuoc, Dang Thi Phuong Thao, Ethyl acetate extract of Elephantopus mollis Kunth induces apoptosis in human gastric cancer cells, BMC Complementary Medecine and Therapies, 21:273;; 2021.
24. T. Truong, H. D. Bui, T. T. V. Pham, L. T. Tran, D. H. Nguyen, C. Ng, T.-H. Le, Occurrences of antibiotic resistant bacteria in a tropical river impacted by anthropogenic activities in Ho Chi Minh City, International Journal of Environmental Science and Technology, 19, 7049–7058; 2022.
25. Quoc-Gia Mai, Hai-Vy Vo-Nguyen, Thuoc Linh Tran, Hieu Tran-Van, All-in-One Molecular Cloning as a New Gene Manipulation Method, Journal of Applied Biotechnology Reports, 9(1):511-515;; 2022.
26. NgocDiem Duong,KhaiHoan NguyenPhuoc,ThuyDung MaiHoang,KimYen Thi Do, TuanBinh Huynh, NguyetThu Thi Nguyen, Thuoc Linh Tran, Hieu TranVan, Fabrication of lateral fow immunoassay strip for rapid detection of acute hepatopancreatic necrosis disease, 3 Biotech 12:243;; 2022.
27. An-Phuc Tran-Mai, Hong-Diep Thi Tran, Quoc-Gia Mai, Kien-Quang Huynh, Thuoc Linh Tran and Hieu Tran-Van, Flagellin from Salmonella enteritidis Enhances the Immune Response of Fused F18 from Enterotoxigenic Escherichia coli, Tropical Life Sciences Research, 33(3), 19–32;; 2022.
28. Khai-Hoan Nguyen-Phuoc, Lan-Vy Pham, Thuoc Linh Tran, Hieu Tran-Van, mMlecular cloning, dual expression, and complex isolation of Toxa and Toxb toxins causing Acute hepatopancreatic necrosis disease (AHPND) in shrimp, Journal of Applied Biological Sciences, 16(2): 182-190; 10.5281/zenodo.6589918; 2022.
29. NgocDiem Duong, ThuyDung MaiHoang, KhaiHoan NguyenPhuoc, KimYen Thi Do, NguyetThu Thi Nguyen, Thuoc Linh Tran, Hieu TranVan, Monitoring the secreted profle of PirAvp and PirBvp toxins from Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease,Aquaculture International;; Epub.10 January 2023.
30. HoangAnh LeDao, ThuanThien Dinh, Thuoc Linh Tran, Vannajan Sanghiran Lee, Hieu TranVan, Molecular Dynamics Simulations Reveal Novel Interacting Regions of Human Prion Protein to Brucella abortus Hsp60 Protein, Molecular Biotechnology;; Epub.12 January 2023.
31. Duy Nguyen-Le, Tien Ngo-My,Tuan Vo-Minh, Cao-Tri Nguyen, Thuoc Linh Tran, Hieu Tran-Van, Astaxanthin prevents hepatosteatosis and hyperlipidemia but not obesity in high-fat diet fed mice, Journal of Microbiology, Biotechnology and Food Sciences, 20xx : x (x) e5950; 2023.

Từ 2017-2022
1. Nguyễn Đức Thịnh, Chu Phạm Ngọc Sơn, Trần Linh Thước, Loại bỏ ảnh hưởng nền trong phân tích kháng sinh cloramphenicol bằng cột sắc ký ái lực miễn dịch, Tạp chí Nghiên cứu dược và Thông tin thuốc, 1, 10-14, 2017.
2. Nguyễn Đức Thịnh, Chu Phạm Ngọc Sơn, Trần Linh Thước, Xác định hàm lượng cloramphenicol trong mẫu cá, mật ong và thức ăn gia súc bằng cột sắc ký ái lực miễn dịch kết hợp với sắc ký lỏng khối phổ, Tạp chí Phân tích Hóa, Lý và Sinh học, 1, 1-6, 2017.
3. Võ Trí Nam, Lê Đăng Lộc, Huỳnh Quốc Việt, Trần Linh Thước, Nguyễn Đức Hoàng, Xây dựng chương trình tối ưu hóa gene dựa trên thuật giải tối ưu đàn kiến cho Escherichia coli, Tạp chí Phát triển Khoa học và Công nghệ ĐHQG-HCM, 2(2): 22-30, 2018.
4. Nguyễn Hoàng Ngọc Phương, Võ Minh Toàn, Lê Dương Vương, Phan Thị Phượng Trang, Trần Linh Thước, Nguyễn Đức Hoàng, Sự phối hợp của endoglucanase A và Exoglucanase S tái tổ hợp tiết bởi tế bào chủ Bacillus subtilis WB800N, Tạp chí Công nghệ Sinh học, 16(1): 157-165, 2018.
5. Bùi Anh Thy, Lê Thanh Hoà, Trần Xuân Hạnh, Trần Linh Thước, Phân tích biến đổi gen của chủng vi rút gây bệnh tai xanh (PRRSV) qua quá trình tiếp truyền trên tế bào từ chủng vi rút thực địa, Tạp chí Phát triển Khoa học và Công nghệ – Khoa học Tự nhiên, 4(4):857-867, DOI : 10.32508/stdjns.v4i4.914, 12/2020.

Từ 2017-2022
Nghiên cứu sản xuất thử nghiệm chế phẩm thuốc tiêm chứa protein G-CSF người tái tổ hợp để điều trị giảm bạch cầu hạt trung tính cho bệnh nhân ung thư; Đề tài cấp Bộ (Đại học Quốc gia TP.HCM); 2018-2021; nghiệm thu 2022.

Từ 2017-2022
Phát triển vector biểu hiện sáp nhập vào bộ gene cảm ứng bằng IPTG và vector biểu hiện không cảm ứng dựa trên promoter Pgrac cho Bacillus subtilis; Nafosted; 2016-2019; nghiệm thu 2020.
Nghiên cứu phát triển que thử phát hiện nhanh hai độc tố ToxA và ToxB của vi khuẩn Vibrio parahaemolyticus gây bệnh hoại tử gan tụy cấp, Acute Hepatopancreatic Necrosis Disease – AHPND, trên tôm nuôi ở Tây Nam Bộ; Đề tài cấp Nhà nước; 2017-2020; nghiệm thu 2021.
Tạo các quyết định độc tố LukF/S-PV, các biến thể của alpha-toxin và ClfA ở B. subtilis và phát triển vector phân phối vaccine B. subtilis kháng lại Staphylococcus aureus; Nafosted; 2019-2022.

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